Friday, August 14, 2015

Development of water-soluble polyanionic carbosilane dendrimers as novel and highly potent topical anti-HIV-2 microbicides

Nanoscale, 2015, Advance Article
DOI: 10.1039/C5NR03644E, Paper
Veronica Briz, Daniel Sepulveda-Crespo, Ana Rita Diniz, Pedro Borrego, Berta Rodes, Francisco Javier de la Mata, Rafael Gomez, Nuno Taveira, M[a] Angeles Munoz-Fernandez
Polyanionic carbosilane dendrimers inhibit HIV-2 binding, inactivate the virus, block cell-to-cell fusion, and enhance the antiviral activity combined with tenofovir/raltegravir.
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