Wednesday, September 03, 2014

Peptide modified gold nanoparticles for improved cellular uptake, nuclear transport, and intracellular retention




Nanoscale , 2014, Advance Article

DOI: 10.1039/C4NR02535K, Paper

C. Yang, J. Uertz, D. Yohan, B. D. Chithrani

A novel hyperspectral imaging technique is used to image GNPs: a combination of three peptides is used for efficient nuclear targeting and improved retention of GNPs targeted into the nucleus is shown for the first time. This is important for future cancer therapeutics as GNPs can be used as radiation dose enhancers and anticancer drug carriers.

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