Thursday, July 24, 2014

Studying the mechanism of CD47-SIRP[small alpha] interactions on red blood cells by single molecule force spectroscopy




Nanoscale , 2014, Advance Article

DOI: 10.1039/C4NR02889A, Communication

Yangang Pan, Feng Wang, Yanhou Liu, Junguang Jiang, Yong-Guang Yang, Hongda Wang

The interactions between SIRP[small alpha] and CD47 were investigated by single-molecule force spectroscopy on both fresh and experimentally aged hRBCs. CD47 experienced a conformation change after oxidation, which may determine the CD47-SIRP[small alpha] signalling switch on the phagocytosis of hRBCs.

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