Nano, Volume 09, Issue 04, June 2014.
Fe3O4–SiO2 core–shell structure nanoparticles containing magnetic properties were investigated for their potential use in drug delivery. The Fe3O4–SiO2 core–shell structure nanoparticles were successfully synthesized by a simple and convenient way. The Fe3O4–SiO2 nanoparticles showed superparamagnetic behavior, indicating a great application potential in separation technologies. From the application point of view, the prepared nanoparticles were found to act as an efficient drug carrier. Specifically, the surface of the core–shell nanoparticles was modified with amino groups by use of silane coupling agent 3-aminopropyltriethoxysilane (APTS). Doxorubicin (DOX) was successfully grafted to the surface of the core–shell nanoparticles after the decoration with the carboxyl acid groups on the surface of amino-modified core–shell structure nanoparticles. Moreover, the nanocomposite showed a good drug delivery performance in the DOX-loading efficiency and drug release experiments, confirming that the materials had a great application potential in drug delivery. It is envisioned that the prepared materials are the ideal agent for application in medical diagnosis and therapy. Superparamagnetic Fe3O4@SiO2 core–shell structure nanoparticles were successfully synthesized. Doxorubicin has been intensively used for the treatment of different types of cancers. In order to apply Fe3O4@SiO2 nanoparticles to drug loading and improve its drug-loading capacity and stability, nanoparticles were modified with amino groups, and then were further functionalized with carboxyl acid groups. The study suggests potential application of modified Fe3O4@SiO2 nanoparticles as a drug delivery vector.
CONG-WANG ZHANG et al
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Fe3O4–SiO2 core–shell structure nanoparticles containing magnetic properties were investigated for their potential use in drug delivery. The Fe3O4–SiO2 core–shell structure nanoparticles were successfully synthesized by a simple and convenient way. The Fe3O4–SiO2 nanoparticles showed superparamagnetic behavior, indicating a great application potential in separation technologies. From the application point of view, the prepared nanoparticles were found to act as an efficient drug carrier. Specifically, the surface of the core–shell nanoparticles was modified with amino groups by use of silane coupling agent 3-aminopropyltriethoxysilane (APTS). Doxorubicin (DOX) was successfully grafted to the surface of the core–shell nanoparticles after the decoration with the carboxyl acid groups on the surface of amino-modified core–shell structure nanoparticles. Moreover, the nanocomposite showed a good drug delivery performance in the DOX-loading efficiency and drug release experiments, confirming that the materials had a great application potential in drug delivery. It is envisioned that the prepared materials are the ideal agent for application in medical diagnosis and therapy. Superparamagnetic Fe3O4@SiO2 core–shell structure nanoparticles were successfully synthesized. Doxorubicin has been intensively used for the treatment of different types of cancers. In order to apply Fe3O4@SiO2 nanoparticles to drug loading and improve its drug-loading capacity and stability, nanoparticles were modified with amino groups, and then were further functionalized with carboxyl acid groups. The study suggests potential application of modified Fe3O4@SiO2 nanoparticles as a drug delivery vector.
CONG-WANG ZHANG et al
Click for full article
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